Experimental strategy for the identification of mTORC1 and 2 substrates in Glioblastoma multiforme (GBM) cell lines and tumors using quantitative multiplex mass spectrometry-based phosphoproteomics.

Experimental strategy for the identification of mTORC1 and 2 substrates in Glioblastoma multiforme (GBM) cell lines and tumors using quantitative multiplex mass spectrometry-based phosphoproteomics.

Research Project 1

Proteomic Approaches to Target the PP6-mTORC2 Pathway in Glioblastoma

Arminja Kettenbach, PhD

Glioblastoma multiforme (GBM) is the most common and aggressive tumor of the central nervous system in adults and it is generally fatal within 12 months of diagnosis. We propose to identify targets in the newly uncovered and frequently overexpressed PP6-mTORC2 pathway for the development of new therapeutic strategies to fight this devastating disease.